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Documentation Index

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Fab fragments contain one complete antigen-binding site with both heavy and light chain variable and constant domains.

Size

~50 kDa (1/3 of IgG)

Valency

Monovalent (1 binding site)

Stability

More stable than scFv

Production

Bacterial, yeast, mammalian

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Structure

Fab maintains the native antibody binding interface while being significantly smaller than full IgG.
  • VH + CH1 domains (heavy chain)
  • VL + CL domains (light chain)
  • Connected by disulfide bonds

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Key Applications

  • Therapeutics - Reduced immunogenicity
  • Diagnostics - Fast tissue penetration
  • Crystallography - Easier to crystallize
  • Research - Structural studies