pSAE denotes exposure‑based heuristics (e.g., percent of solvent‑accessible exposed hydrophobic surface or residues) used to estimate aggregation risk.
  • Type: Exposure metric (solvent‑accessible hydrophobic exposure)
  • Goal: Identify/flag aggregation‑prone designs
  • Input: 3D structure or predicted SASA; sequence‑derived proxies (hydropathy windows)
Notes: Implementations vary across toolkits; ensure consistent residue/burial definitions.