IgG is the standard full-length antibody format used in most therapeutic monoclonal antibodies, featuring two identical antigen-binding sites.

Size

~150 kDa

Valency

Bivalent (2 binding sites)

Half-life

~3 weeks in humans

Production

Mammalian cells

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Structure Components

  • Heavy chains (2x ~50 kDa) + Light chains (2x ~25 kDa)
  • Fc region - Enables effector functions
  • Fab regions - Two identical antigen-binding sites
  • Hinge region - Provides flexibility
Most common therapeutic format with strong effector functions
IgG represents the gold standard for therapeutic antibodies due to its bivalent binding, long half-life, and well-characterized manufacturing processes.