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Documentation Index

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ProteinMPNN designs sequences for a fixed backbone by maximizing sequence-backbone compatibility via message passing. Widely used for inverse folding and binder design.

Type

Inverse folding (sequence design)

Input

Backbone coordinates (PDB)

Output

Sequences consistent with backbone

Origin

Baker Lab

Resources

Pair with structure predictors (e.g., ESMFold/AlphaFold2) to validate designed sequences.