Binding Screening

Our Protein Binding Screening workflow enables users to easily design new protein binders and characterize their interaction to one or several protein targets of interest. The assay is designed to serve as entry point into the discovery process and validation of protein interactions and provides a quick filter to separate promising candidates from other sequences, enabling faster and more targeted assays downstream.

The workflow is designed to capture a wide range of molecular interactions ranging from low micromolar (uM) to low picomolar (pM) dissociation constants. This workflow includes the design and synthesis of the DNA coding for your protein, the expression of the protein variants in cell-free and their characterization using our binding screening workflow.

You will be able to access the following information for each interaction pair:

• Protein Expression and Yield

• Binding Strength Rank

• Including an estimate of Dissociation Constant (KD) and Kinetic Parameters (Kon and Koff)

• Quality Control and confidence level

After the workflow is completed, you will be able to explore the data directly in our foundry portal, compare results across experiments and select variants to be characterized on our other available workflows.