Adaptyv Bio - Docs
  • Getting started
  • Experiment Types
    • Binding Screening
    • Affinity Characterization
    • Epitope Binning
    • Thermostability
    • Custom Assay Development
  • Molecular and Target Scope
    • Supported Protein Formats
    • Target Characteristics
  • Project Workflow
    • 1. Experiment Configuration
    • 2. Build Phase
    • 3. Data Generation (Protein Testing)
    • 4. Analysis, Validation, and Reporting
  • Project Scale and Timelines
    • Pilot Projects
    • Project Scaling
    • Timelines and Communication
  • Technology
    • Biolayer Interferometry
  • Foundry FAQs
    • Binding Assays
  • Foundry Portal
    • Creating Experiments
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  1. Experiment Types

Binding Screening

Last updated 4 months ago

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Protein binding screening is designed to quickly and efficiently evaluate large libraries of protein variants for their ability to bind a target of interest. This high-throughput workflow enables you to classify candidates as binders or non-binders while also categorizing their binding strength (e.g., weak, medium, or strong). By focusing on rapid and cost-effective assays, our screening service is ideal for early-stage discovery projects where prioritizing candidates is key.

Key Features:

  • Starts at 99$/protein. 21 days turnaround time.

  • Yes/No Binding Classification: Rapidly determine whether each variant binds to the target.

  • Binding Strength Categorization: Classifies binders as weak, medium, or strong (no KD values).

  • High Throughput: Capable of screening thousands of variants in a single campaign.

  • Cost-Effective: Optimized for large-scale projects without compromising data quality.

When to Use:

  • To triage large libraries of protein variants during early discovery phases.

  • To identify promising binders for subsequent detailed characterization.

  • When rapid and broad insights into binding potential are required.

How It Works

If you need precise binding kinetics with KD values, see

During a binding screen, protein variants are immobilized or presented in solution, and the target analyte is flowed over the experimental setup. Real-time binding events are monitored using (BLI), and results are analyzed to classify each variant. Single-concentration measurements provide approximate binding strength, allowing you to prioritize strong binders while excluding non-binders or weak candidates

Affinity Characterization.
bio-layer interferometry