Changelog

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Enhanced Protein Analysis Capabilities

We’re excited to announce major enhancements to our protein analysis portfolio, expanding our capabilities in antibody characterization and thermal stability analysis.

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New Features

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Fab Mapping Support

• Complete Fab fragment characterization: Full support for Fab fragment mapping and epitope analysis
• Antibody engineering optimization: Detailed epitope analysis for antibody engineering projects
• Cross-reactivity studies: Comprehensive species and variant cross-reactivity assessment
• Kinetic characterization: Full binding kinetics analysis for Fab fragments

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Advanced Thermostability with nanoDSF

• High-precision measurements: Integration of nanoDSF readouts for thermal stability analysis
• Dual detection modes: Simultaneous fluorescence and light scattering detection
• Enhanced sensitivity: Detection of subtle thermal transitions and aggregation events
• Automated analysis: Advanced algorithms for Tm and Tagg determination

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Flexible Tag Positioning

• N-terminal and C-terminal options: Support for optimal tag placement based on protein structure
• Multiple tag systems: His-tag, FLAG-tag, Strep-tag, and GST-tag compatibility
• Intelligent recommendations: AI-driven tag placement optimization
• Functional validation: Ensuring tag placement maintains protein activity

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Improvements

• Enhanced protein construct configurator with intelligent tag placement recommendations
• Automated buffer optimization for thermostability assays based on protein characteristics
• Improved data visualization for complex thermal transition analysis

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Expanded Assay Portfolio

This release focuses on expanding our analytical capabilities with new assay types and enhanced detection methods.

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New Assay Types

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Fab Fragment Analysis

• Dedicated workflows: Specialized protocols for Fab fragment binding kinetics
• Stability assessment: Comprehensive thermal and chemical stability profiling
• Comparative analysis: Side-by-side comparison of different Fab variants
• Quality metrics: Detailed purity and aggregation analysis

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nanoDSF Integration

• Label-free profiling: Advanced thermostability analysis without external dyes
• Dual parameter measurement: Simultaneous Tm and Tagg determination
• High-throughput capability: 48-sample capacity for screening applications
• Method validation: Fully validated protocols for regulatory compliance

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Enhanced Tag Configuration

• Multiple tag options: Expanded support for various affinity tags
• Position flexibility: N-terminal, C-terminal, and internal tag placement
• Optimization protocols: Systematic approach to tag selection and positioning
• Quality control: Comprehensive tag functionality validation

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Platform Improvements

• Optimized expression protocols for tagged protein variants with improved yields
• Enhanced data analysis algorithms for complex binding interactions
• Streamlined workflow management for high-throughput projects

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Bug Fixes

• Improved handling of proteins with multiple melting transitions in thermostability analysis
• Enhanced baseline correction algorithms for nanoDSF measurements
• Fixed edge cases in tag removal efficiency calculations

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Platform Performance Enhancements

Significant improvements to platform performance, user experience, and data quality.

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Performance Improvements

• Faster turnaround times: Reduced processing time for affinity characterization by 30%
• Enhanced throughput: Increased capacity for high-throughput screening projects
• Improved data quality: Advanced quality control algorithms for more reliable results
• Streamlined workflows: Optimized experimental protocols for efficiency

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User Experience

• Enhanced Foundry Portal: Improved user interface with better navigation
• Real-time tracking: Live project status updates with detailed progress indicators
• Advanced filtering: Enhanced search and filter capabilities for project management
• Mobile optimization: Improved mobile device compatibility

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Data Analysis

• Advanced analytics: New statistical analysis tools for binding data interpretation
• Automated reporting: Enhanced report generation with customizable formats
• Data visualization: Improved charts and graphs for better data interpretation
• Export options: Multiple file format support for data export

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API and Integration Enhancements

New API capabilities and third-party integrations to streamline your research workflows.

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API Development

• RESTful API: Comprehensive API for programmatic access to platform features
• Authentication: Secure token-based authentication system
• Rate limiting: Intelligent rate limiting to ensure platform stability
• Documentation: Interactive API documentation with code examples

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Integration Capabilities

• LIMS integration: Direct integration with popular Laboratory Information Management Systems
• Data export: Automated data export to external databases and storage systems
• Workflow automation: API-driven workflow automation for repetitive tasks
• Custom integrations: Support for custom integration development

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Developer Tools

• SDK availability: Python and R SDKs for easy integration
• Code examples: Comprehensive code examples and tutorials
• Webhook support: Real-time notifications for experiment completion
• Testing environment: Sandbox environment for integration testing

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Quality Control and Compliance Updates

Enhanced quality control measures and regulatory compliance features.

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Quality Enhancements

• Advanced QC metrics: Expanded quality control parameters for all assay types
• Statistical validation: Enhanced statistical analysis for result validation
• Batch tracking: Comprehensive batch-to-batch consistency monitoring
• Control standards: New reference standards for improved accuracy

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Regulatory Compliance

• GLP compliance: Good Laboratory Practice protocols implementation
• Data integrity: Enhanced data integrity measures and audit trails
• Validation protocols: Comprehensive method validation documentation
• 21 CFR Part 11: Electronic records compliance for regulated industries

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Documentation

• Standard Operating Procedures: Updated SOPs for all experimental protocols
• Validation reports: Detailed analytical method validation reports
• Quality manuals: Comprehensive quality system documentation
• Training materials: Enhanced training resources for users

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Platform Beta Launch

Official beta launch of the Adaptyv Bio cloud laboratory platform with core functionality.

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Core Features

• Binding screening assays: High-throughput binding screens with KD determination
• Affinity characterization: Detailed kinetic analysis with full rate constant determination
• Epitope binning: Automated epitope binning workflows for antibody characterization
• Thermostability assessment: Comprehensive thermal stability analysis
• Foundry Portal: Web-based platform for experiment design and management

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Supported Formats

• Antibodies: Full-length antibodies, Fab fragments, and single-chain variants
• Proteins: Recombinant proteins, enzymes, and binding domains
• Peptides: Linear and cyclic peptides for binding studies
• Custom formats: Flexible support for novel protein formats

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Technology Stack

• BLI technology: Bio-layer interferometry for real-time binding analysis
• Cell-free expression: Rapid protein production for screening applications
• Quality control: Comprehensive analytical characterization of all proteins