Human PD-1
Programmed cell death protein 1 (PD-1) is a cell surface receptor that plays a critical role in regulating the immune system.
Function
Programmed cell death protein 1 (PD-1), also known as CD279, is a cell surface receptor that belongs to the immunoglobulin superfamily. It is expressed on T cells, B cells, and monocytes and is a potent regulator of immune responses. PD-1 and its ligands are a promising therapeutic target for a variety of cancers.
Structure
Human PD-1 has an immunoglobulin variable-like (IgV) domain structure that is characteristic of immune checkpoint receptors. The protein’s structure reveals important binding interfaces with its ligands PD-L1 and PD-L2, which are critical for understanding immune regulation mechanisms.