Binding Data Package

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Getting Started

1. Download the package.zip archive from the Foundry Portal (Download Data → Download additional raw data).
2. Unzip and open the extracted package/ directory.
3. Use the sections below as a field guide while browsing.

All contents are safe to share publicly and ready for downstream analysis or visual inspection.

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Folder Overview

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kinetics/

PNG sensorgrams for each sample replicate, named <name>_<replicate>.png. Use these plots for quick visual QC without loading raw data.

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raw_data/

CSV exports of the instrument readouts, using <name>_<replicate>_<concentration>.csv. Columns:

• t: time in seconds
• y: instrument response in nanometers

Additional notes:

• Values are rounded to three decimals to reduce package size.
• Neutralisation controls follow control_<index>_<concentration>.csv and share the same schema.

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fit_data/

Modelled sensorgrams for replicates with approved fits (t, y columns), matching the raw_data/ filename convention. Overlay these with the raw traces to reproduce kinetics calculations.

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aux/

Metadata lives in replicate_info.csv:

• name: OS-safe protein identifier
• replicate: replicate index
• method: BLI or SPR
• MAE: mean absolute error (two decimals)
• rel_MAE: MAE normalized by maximum signal
• rmax_estimate: estimated Rmax value

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blanks/ (when provided)

Background and reference material for the experiment.

• raw_data/
  • <blank_run>_<index>.csv: blank curves (t, y)
  • read_data.csv: metadata with read, run, concentration_nM, filename
• figures/
  • blank_<run>.png: visualizations of blank sensorgrams
• run_mapping.csv
  • Columns: name, replicate, runs — shows blank runs tied to each replicate.

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Additional Notes

• Filenames replace spaces and special characters with underscores for compatibility.
• Folder structure is machine-readable and works well with automated pipelines.
• Each archive reflects the current data version; redownload after updates to stay in sync.