> ## Documentation Index
> Fetch the complete documentation index at: https://docs.adaptyvbio.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Miniproteins

> De novo or engineered small proteins with stable, designed folds

Miniproteins are compact protein scaffolds (typically \< 80 amino acids) engineered or designed to adopt specific, stable folds for binding or catalysis.

<CardGroup cols={2}>
  <Card title="Size" icon="ruler">
    \~3–10 kDa (30–90 aa)
  </Card>

  <Card title="Folding" icon="atom">
    Stable designed topologies (helix bundles, β-sheets)
  </Card>

  <Card title="Stability" icon="shield">
    High thermostability; protease resistant when well-packed
  </Card>

  <Card title="Production" icon="bacteria">
    Bacterial or cell-free expression; chemical synthesis
  </Card>
</CardGroup>

## Unique Features

<Tip>
  Computational design enables shape-complementary interfaces with high affinity and specificity.
</Tip>

* **De novo scaffolds** not constrained by natural antibody frameworks
* **High expression** and straightforward manufacturing
* **Robustness** for harsh assay and environmental conditions

<Warning>
  Design accuracy and foldability depend on sequence-structure mapping; experimental validation is essential.
</Warning>

## Applications

<Tabs>
  <Tab title="Binders">
    Target-specific binding domains for therapeutics, diagnostics, and targeting.
  </Tab>

  <Tab title="Enzyme Mimetics">
    Small catalytic scaffolds or cofactor-binding mini-enzymes.
  </Tab>

  <Tab title="Scaffolding">
    Modular components in synthetic biology and nanotechnology.
  </Tab>
</Tabs>

<Note>
  Miniproteins bridge the gap between peptides and antibodies: small, stable, and engineerable with tailor-made interfaces.
</Note>