> ## Documentation Index
> Fetch the complete documentation index at: https://docs.adaptyvbio.com/llms.txt
> Use this file to discover all available pages before exploring further.

# pSAE

> Percent Solvent‑Accessible Exposed hydrophobicity (and related exposure metrics)

pSAE denotes exposure‑based heuristics (e.g., percent of solvent‑accessible exposed hydrophobic surface or residues) used to estimate aggregation risk.

* **Type**: Exposure metric (solvent‑accessible hydrophobic exposure)
* **Goal**: Identify/flag aggregation‑prone designs
* **Input**: 3D structure or predicted SASA; sequence‑derived proxies (hydropathy windows)

Notes: Implementations vary across toolkits; ensure consistent residue/burial definitions.