> ## Documentation Index
> Fetch the complete documentation index at: https://docs.adaptyvbio.com/llms.txt
> Use this file to discover all available pages before exploring further.

# ESM

> Evolutionary Scale Modeling: protein LMs for representation, structure, and design

<Info>
  ESM is a family of large protein language models trained on evolutionary-scale sequence data. Variants (ESM-1b/2/ESMFold/ESM-3) support representation learning, zero-shot mutational effects, and structure prediction.
</Info>

<CardGroup cols={2}>
  <Card title="Type" icon="layer-group">Protein language model</Card>
  <Card title="Primary tasks" icon="list">Embeddings, structure prediction (ESMFold), design</Card>
  <Card title="Input" icon="download">Amino acid sequences (e.g., FASTA)</Card>
  <Card title="Origin" icon="building">Meta AI</Card>
  <Card title="License" icon="scale-balanced">MIT</Card>
</CardGroup>

## Resources

* GitHub: [facebookresearch/esm](https://github.com/facebookresearch/esm)
* Paper (ESMFold): [Protein structure prediction using ESM](https://www.science.org/doi/10.1126/science.ade2574)
* Model card(s): see repo

<Tip>
  Use ESM embeddings for downstream tasks (e.g., fitness prediction) or ESMFold for fast single-sequence structure prediction.
</Tip>