> ## Documentation Index
> Fetch the complete documentation index at: https://docs.adaptyvbio.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Cross-Lab Validation

> Our binding calls run against an independent lab's on the same designs, with the raw traces from both labs public.

In August 2026 Anthropic had 1,440 Claude-designed miniproteins synthesized and tested independently by two labs, Adaptyv Bio and Twist Bioscience, neither able to see the other's data. The two labs ran genuinely different formats: cell-free monovalent designs on single-cycle SPR here, HEK293-expressed Fc fusions on a high-throughput SPR array there.

On the 1,235 designs measured at both labs, our binder and non-binder calls agreed with Twist's **89% of the time**, with a Cohen's κ of 0.71.

The raw sensorgrams, fits and per-design labels from both labs are public under CC BY 4.0, so the comparison can be redone rather than taken on trust.

<Card title="Autonomous de novo protein binder design with Claude" icon="file-lines" href="https://www-cdn.anthropic.com/30bf50e22a01388bb29bf077ee3f244531594b7a.pdf">
  The full report, 18 August 2026, including the assay conditions at both labs and the adjudication rule used where they disagreed.
</Card>

<Card title="Anthropic/claude-protein-binder-design" icon="database" href="https://huggingface.co/datasets/Anthropic/claude-protein-binder-design">
  Raw traces, fits and per-design labels from both labs, plus the computational models for all 1,440 designs.
</Card>

<Note>
  Agreement here is on binder versus non-binder, not on KD. The two formats differ in valency, so the affinity values are not directly comparable, and the report does not claim otherwise.
</Note>

## Related pages

* [Binding](/docs/experiment-types/binding)
* [Binding Data Package](/docs/experiment-setup/binding-data-package), the raw traces and fits you get from your own runs
* [SPR technology overview](/wiki/technologies/SPR)


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